Molecular and genomic characterization of pathogenic traits of group A Streptococcus pyogenes
-
- HAMADA Shigeyuki
- Research Institute for Microbial Diseases, Japan-Thailand Collaboration Center for Emerging and Reemerging Infections, Osaka University
-
- KAWABATA Shigetada
- Department of Oral and Molecular Microbiology, Graduate School of Dentistry, Osaka University
-
- NAKAGAWA Ichiro
- Department of Microbiology, Graduate School of Medicine, Kyoto University
書誌事項
- タイトル別名
-
- Molecular and genomic characterization of pathogenic traits of group A <i>Streptococcus pyogenes</i>
この論文をさがす
抄録
Group A streptococcus (GAS) or Streptococcus pyogenes causes various diseases ranging from self-limiting sore throat to deadly invasive diseases. The genome size of GAS is 1.85–1.9 Mb, and genomic rearrangement has been demonstrated. GAS possesses various surface-associated substances such as hyaluronic capsule, M proteins, and fibronectin/laminin/immunoglobulin-binding proteins. These are related to the virulence and play multifaceted and mutually reflected roles in the pathogenesis of GAS infections. Invasion of GAS into epithelial cells and deeper tissues provokes immune and non-immune defense or inflammatory responses including the recruitment of neutrophils, macrophages, and dendritic cells in hosts. GAS frequently evades host defense mechanisms by using its virulence factors. Extracellular products of GAS may perturb cellular and subcellular functions and degrade tissues enzymatically, which leads to the aggravation of local and/or systemic disorders in the host. In this review, we summarize some important cellular and extracellular substances that may affect pathogenic processes during GAS infections, and the host responses to these.
収録刊行物
-
- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
-
Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 91 (10), 539-559, 2015
日本学士院
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204147039616
-
- NII論文ID
- 130005129678
-
- NII書誌ID
- AA00785485
-
- ISSN
- 13492896
- 03862208
-
- NDL書誌ID
- 027004025
-
- PubMed
- 26666305
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可