Lactobacillus rhamnosus L60, a potential probiotic isolated from the human vagina
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- Pascual Liliana M.
- Departamento de Microbiología e Inmunología
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- Daniele María B.
- Departamento de Microbiología e Inmunología
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- Ruiz Francisco
- Departamento de Microbiología e Inmunología
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- Giordano Walter
- Departamento de Biología Molecular,Universidad Nacional de Río Cuarto
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- Pájaro Cristina
- Departamento de Microbiología e Inmunología
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- Barberis Lucila
- Departamento de Microbiología e Inmunología
説明
The vagina has been increasingly viewed as an "ecosystem" whose normal microflora help protect it from invading pathogens, including those that cause urinary tract infections and sexually transmitted diseases. We tested new strains of lactobacilli as potential probiotics for maintenance of urogenital tract health, as well as prevention and therapy of urogenital infections. A strain of lactobacilli isolated from the vagina of nonpregnant, healthy, premenopausal women was identified as Lactobacillus rhamnosus L60 by 16S rDNA sequence homology. L60 was evaluated for antimicrobial activity, in vitro antibiotic resistance, autoaggregation, surface hydrophobicity, co-aggregation with other bacterial species, hydrogen peroxide (H2O2) production, and bacterial adherence. It displayed a wide spectrum of antimicrobial activity against urogenital pathogens, and resistance to antibiotics commonly prescribed for infections caused by these pathogens. L60 produced H2O2, adhered to vaginal epithelial cells, co-aggregated with Escherichia coli and Candida albicans, and displayed self-aggregation. In view of these characteristics, L60 is considered a potential probiotic, and will be further evaluated for preventive and therapeutic application locally in the vaginal tract.
収録刊行物
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- The Journal of General and Applied Microbiology
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The Journal of General and Applied Microbiology 54 (3), 141-148, 2008
公益財団法人 応用微生物学・分子細胞生物学研究奨励会
