Production of new anthracycline antibiotics 1-hydroxyoxaunomycin and 6-deoxyoxaunomycine by limited biosynthetic conversion using a daunorubicin-negative mutant.
-
- YOSHIMOTO AKIHIRO
- Central Research Laboratories, Mercian Corporation Present address: Laboratories for Microbial Biochemistory, Faculty of Applied Biological Science, Hiroshima University
-
- JOHDO OSAMU
- Central Research Laboratories, Mercian Corporation
-
- TONE HIROSHI
- Central Research Laboratories, Mercian Corporation
-
- OKAMOTO ROKUROU
- Central Research Laboratories, Mercian Corporation
-
- NAGANAWA HIROSHI
- Institute of Microbial Chemistry
-
- SAWA TSUTOMU
- Institute of Microbial Chemistry
-
- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
Abstract
A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolation and purification from bioconversion broth, structural determination and antitumor activities against leukemic L1210 cells are described.
Journal
-
- The Journal of Antibiotics
-
The Journal of Antibiotics 45 (10), 1609-1617, 1992
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION