Biosynthesis of anthracycline antibiotics by Streptomyces galilaeus. I. Glycosidation of various anthracyclinones by an aclacinomycin-negative mutant and biosynthesis of aclacinomycins from aklavinone.
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- OKI TOSHIKAZU
- Central Research Laboratories, Sanraku-Ocean Co. Ltd.
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- YOSHIMOTO AKIHIRO
- Central Research Laboratories, Sanraku-Ocean Co. Ltd.
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- MATSUZAWA YASUE
- Central Research Laboratories, Sanraku-Ocean Co. Ltd.
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
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- UMEZAWA HAMAO
- Institute of Microbial Chemistry
書誌事項
- タイトル別名
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- I. GLYCOSIDATION OF VARIOUS ANTHRACYCLINONES BY AN ACLACINOMYCINNEGATIVE MUTANT AND BIOSYNTHESIS OF ACLACINOMYCINS FROM AKLAVINONE
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説明
An aclacinomycin-negative mutant strain KE303 which required aklavinone aglycone for the production of anthracycline antibiotics was derived from Streptomyces galilaeus, and employed for the glycosidation of various anthracyclinones. ε-, γ- and β-Rhodomycinones, ε-isorhodomycinone, ε- and β-pyrromycinones and chemically modified aklavinones were found to be glycosidated to the biologically active anthracyclines, when they were fed to the growing culture. However, the feeding of daunomycinone, 13-deoxydaunomycinone, adriamycinone and steffimycinone did not yield any glycoside. The bioconversion of presumptive precursor glycosides revealed that aclacinomycin A is biosynthesized by the step-wise glycosidation from aklavinone via aklavin and MA144 S1.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 33 (11), 1331-1340, 1980
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