Oximidine III, a New Antitumor Antibiotic against Transformed Cells from Pseudomonas sp. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity

DOI PubMed 被引用文献3件 参考文献11件 オープンアクセス
  • HAYAKAWA YOICHI
    Institute of Molecular and Cellular Biosciences, The University of Tokyo
  • TOMIKAWA TAIJIRO
    Institute of Molecular and Cellular Biosciences, The University of Tokyo
  • SHIN-YA KAZUO
    Institute of Molecular and Cellular Biosciences, The University of Tokyo
  • ARAO NAKAKO
    Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd.
  • NAGAI KOJI
    Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd.
  • SUZUKI KEN-ICHI
    Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd.

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  • I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity

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Our screening for antitumor antibiotics against transformed cells resulted in the isolation of a new active metabolite, oximidine III, from Pseudomonas sp. QN05727. This substance selectively inhibited the growth of rat 3Y1 fibroblasts transformed with various oncogenes. In ras- or src-transformed cells, oximidine III arrested the cell cycle at G1 phase and increased the expression of p21WAF1

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