Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities.
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- TAKAHASHI HIDETOSHI
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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- OSADA HIROYUKI
- Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
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- KOSHINO HIROYUKI
- Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
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- SASAKI MUTSUMI
- Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
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- ONOSE RIE
- Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
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- NAKAKOSHI MASAMICHI
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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- YOSHIHAMA MAKOTO
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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- ISONO KIYOSHI
- Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research Present address: Department of Marine Science, School of Marine Science and Technology, Tokai University
書誌事項
- タイトル別名
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- II. BIOLOGICAL ACTIVITIES
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説明
Reveromycins A, B, C and D showed inhibitory activity against EGF-stimulated mitogen response in Balb/MK cells. Furthermore reveromycins A, C and D exhibited morphological reversion of srcts-NRK cells, antiproliferative activity against human tumor cell lines and antifungal activity. The effects of reveromycins A, C and D on eukaryotic cells were closely similar to each other, but those of reveromycin B were very weak. In vitro studies revealed that reveromycin A is a selective inhibitor of protein synthesis in eukaryotic cells.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 45 (9), 1414-1419, 1992
公益財団法人 日本感染症医薬品協会