AT2433-A1, AT2433A2, AT2433-B1 and AT2433-B2 novel antitumor compounds produced by Actinomadura melliaura. II. Structure determination.
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- GOLIK JERZY
- Pharmaceutical Research and Development Division, Bristol-Myers Company
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- DOYLE TERRENCE W.
- Pharmaceutical Research and Development Division, Bristol-Myers Company
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- KRISHNAN BALA
- Pharmaceutical Research and Development Division, Bristol-Myers Company
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- DUBAY GEORGE
- Pharmaceutical Research and Development Division, Bristol-Myers Company
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- MATSON JAMES A.
- Pharmaceutical Research and Development Division, Bristol-Myers Company
書誌事項
- タイトル別名
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- II. STRUCTURE DETERMINATION
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説明
The chemical structures of AT2433-A1 (2), AT2433-A2 (3), AT2433-B1 (4) and AT2433-B2 (5) were elucidated by degradation and spectroscopic studies. Compounds 2-5 are disaccharides closely related to rebeccamycin. The aglycone in 2 and 3 was determined to be 6-N-methyl-11-chloro-5H-indolo[2, 3-a]pyrolo[3, 4-c]carbazole and in 4 and 5 it was determined to be 6-N-methyl-5H-indolo[2, 3-a]pyrolo[3, 4-c]carbazole. Compounds 2 and 4 are 4-N"-methyl analogs of 3 and 5.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 42 (12), 1784-1789, 1989
公益財団法人 日本感染症医薬品協会