Arohynapenes A and B, new anticoccidial agents produced by Penicillium sp. Taxonomy, fermentation, and structure elucidation.

DOI PubMed 4 Citations
  • MASUMA ROKURO
    Research Center for Biological Function, The Kitasato Institute
  • TABATA NORIKO
    Research Center for Biological Function, The Kitasato Institute
  • TOMODA HIROSHI
    Research Center for Biological Function, The Kitasato Institute
  • HANEDA KATSUJI
    Research Center for Biological Function, The Kitasato Institute
  • IWAI YUZURU
    Research Center for Biological Function, The Kitasato Institute
  • OMURA SSTOSHI
    Research Center for Biological Function, The Kitasato Institute

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Other Title
  • TAXONOMY, FERMENTATION, AND STRUCTURE ELUCIDATION

Abstract

Penicillium sp. FO-2295, a water isolate, was found to produce a series of new anticoccidial compounds. Two active compounds, designated arohynapenes A and B, were isolated from the fermentation broth of the producing strain by solvent extraction and preparative HPLC. Arohynapene A was deduced to be(2E, 4E)-5-(5-hydroxy-2, 6, 8-trimethyl-5, 6, 7, 8-tetrahydronaphtalene)-2, 4-pe ntadienoic acid, and arohynapene B was (2E, 4E)-5-(2-hydroxymethyl-6, 8-dimethyl-5, 6, 7, 8-tetrahydronaphtalene)-2, 4-p entadienoic acid. Arohynapenes inhibited the growth of Eimeria tenella in an in vitro assay using BHK-21 cells as a host. No schizont in the cells was observed at concentrations ranging above 35.0 μM and 7.0 μM for arohynapenes A and B, respectively.

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Details 詳細情報について

  • CRID
    1390001204148586368
  • NII Article ID
    130003502609
  • DOI
    10.7164/antibiotics.47.46
  • COI
    1:CAS:528:DyaK2cXitl2kt70%3D
  • ISSN
    18811469
    00218820
    http://id.crossref.org/issn/00218820
  • PubMed
    8119861
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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