New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica.
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- SUZUKI YOSHIHIRO
- Graduate School of Bioagricurtural Sciences, Nagoya University
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- OJIKA MAKOTO
- Graduate School of Bioagricurtural Sciences, Nagoya University
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- SAKAGAMI YOUJI
- Graduate School of Bioagricurtural Sciences, Nagoya University
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- KAIDA KENICHI
- Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
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- FUDOU RYOSUKE
- Central Research Laboratories, Ajinomoto Co., Inc.
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- KAMEYAMA TOSHIYUKI
- Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
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説明
The structures of new cyclic decadepsipeptides, clavariopsins A and B, were determined to be cyclo[-(R)-2-hydroxyisovaleryl-L-pipecolyl-L-MeVal-L-Val-L-MeAsp-L-Mene-L-Melle-Gly-L-MeVal-L-Tyr(OMe)-] and cyclo[-(R)-2-hydroxyisovaleryl-L-pipecolyl-L-Val-L-Val-L-MeAsp-L-Melle-L-Melle-Gly-L-MeVal-L-Tyr(OMe)-], respectively, by spectroscopic analyses, especially using 2D NMR techniques. The absolute stereochemistry was elucidated by the advanced MARFEY'S method and chiral HPLC analysis.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 54 (1), 22-28, 2001
公益財団法人 日本感染症医薬品協会
