Unusual Transformation of the 3-Hydroxy-picolinoyl Residue of Pristinamycin IA.

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説明

Pristinamycin IA was modified in a two-step procedure to give original derivatives possessing a tricyclic nucleus (8a, 8b, 8c) or a substituted pyrrole ring (10a, 10b) in place of the natural exocyclic 3-hydroxy-picolinoyl residue. This transformation involved firstly preparation of pyridinium betaines 5 from pristinamycin IA and secondly a 1-3 dipolar cycloaddition between 5 and N-substituted maleimides or diethyl ace tylenedicar boxy late. The compounds obtained were evaluated as antibacterial agents alone and in association with pristinamycin IIA.

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詳細情報 詳細情報について

  • CRID
    1390001204149136000
  • NII論文ID
    10004794220
  • NII書誌ID
    AA0069330X
  • DOI
    10.7164/antibiotics.48.676
  • ISSN
    18811469
    00218820
  • PubMed
    7649868
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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