Antifungal Antibiotic Benanomicin A Increases Susceptibility of Candida albicans to Phagocytosis by Murine Macrophages.
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- WATABE HIROOMI
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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- MIKUNIYA TAKESHI
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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- INOUYE SHIGEHARU
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd. Present address: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
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- ABE SHIGERU
- Department of Microbiology and Immunology, Teikyo University School of Medicine
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- YAMAGUCHI HIDEYO
- Department of Microbiology and Immunology, Teikyo University School of Medicine
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- KONDO SHINICHI
- Institute of Microbial Chemistry
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
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- KLEIN THOMAS W.
- Department of Medical microbiology and immunology, University of South Florida College of Medicine
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- FRIEDMAN HERMAN
- Department of Medical microbiology and immunology, University of South Florida College of Medicine
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- YAMAMOTO YOSHIMASA
- Department of Medical microbiology and immunology, University of South Florida College of Medicine
Bibliographic Information
- Other Title
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- Antifungal Antibiotic Benanomicin A Inc
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Abstract
Benanomicin A is an antifungal antibiotic produced by Actinomadura spadix. In the present study, we investigated the effect of benanomicin A on the phagocytosis of Candida albicans by murine peritoneal macrophages and on the cell-surface hydrophobicity (CSH) of C. albicans. Although pretreatment of macrophages with benanomicin A had no effect on the phagocytosis, addition of benanomicin A to the culture of macrophages and Candida cells increased the susceptibility of Candida cells to the phagocytosis by the macrophages. Pretreatment of Candida cells with benanomicin A also increased the susceptibility of Candida cells to the phagocytosis. When Candida cells were mixed with benanomicin A, the antibiotic bound irreversibly to Candida cells. These data suggest the possibility that the increased susceptibility of Candida cells to the phagocytosis is mediated by the binding of benanomicin A to Candida cells. Examination of physicochemical property of Candida cell surface showed that the CSH of Candida cells significantly decreased by the treatment with benanomicin A. Thus, binding of benanomicin A to Candida cells may induce biochemical/physicochemical alternation of the surfaces, so that they become more susceptible to phagocytosis by murine macrophages. These properties of benanomicin A, along with its antifungal activity, seem to be beneficial in the treatment of fungal infections.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 49 (12), 1221-1225, 1996
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Details 詳細情報について
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- CRID
- 1390001204149368320
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- NII Article ID
- 130003503068
- 10005518613
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- NII Book ID
- AA0069330X
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- COI
- 1:CAS:528:DyaK2sXhs1Chtg%3D%3D
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- ISSN
- 18811469
- 00218820
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- NDL BIB ID
- 4121863
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- PubMed
- 9031667
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed