Studies on .BETA.-lactam antibiotics. II Synthesis and structure-activity relationships of .ALPHA.-hydroxyiminoarylacetyl cephalosporins.

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Other Title
  • SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF α-HYDROXYIMINOARYLACETYL CEPHALOSPORINS

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Description

The synthesis and antibacterial activity in vitro of the 2-aryl-2-hydroxyiminoacetyl cephalosporins (2) are described. Within this cephalosporin series, analogs (9f-13f) with 2-hydroxyimino -2-(3-hydroxyphenyl)acetyl group at the 7-position of a cephem nucleus were found to have the highest antibacterial activity against a wide-range of microorganisms, including β-lactamaseproducing bacteria. Structure-activity relationships of 2 are discussed.

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Details 詳細情報について

  • CRID
    1390001204149656704
  • NII Article ID
    130003499958
  • DOI
    10.7164/antibiotics.34.1290
  • COI
    1:CAS:528:DyaL3MXmtFGltbY%3D
  • ISSN
    18811469
    00218820
  • PubMed
    7309623
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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