Chondramides AD, new antifungal and cytostatic depsipeptides from Chondromyces crocatus (Myxobacteria)
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- KUNZE BRIGITTE
- GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie
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- JANSEN ROLF
- GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffchemie
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- SASSE FLORENZ
- GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie
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- HÖFLE GERHARD
- GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffchemie
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- REICHENBACH HANS
- GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie
書誌事項
- タイトル別名
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- Chondramides A - D, New Antifungal and Cytostatic Depsipeptides from Chondromyces crocatus (Myxobacteria). Production, Physico-chemical and Biological Properties.
- Production, Physico-chemical and Biological Properties
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説明
Novel depsipeptides, named chondramides were produced at levels up to 4.3 mg/liter by several myxobacteria of the genus Chondromyces. The compounds are structurally closely related to jaspamide/jasplakinolide from marine sponges of the genus Jaspis. Initially the chondramides were detected in acetone extracts of the biomass of Chondromyces crocatus, strain Cm c2. So far, four structural variants could be characterized, the chondramides A-D. They inhibited the growth of a few yeasts and showed high cy to static activity against cultivated human and animal cells.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 48 (11), 1262-1266, 1995
公益財団法人 日本感染症医薬品協会