A new antitumor substance, BE-18591, produced by a streptomycete. I. Fermentation, isolation, physico-chemical and biological properties.

  • KOJIRI KATSUHISA
    New Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
  • NAKAJIMA SHIGERU
    New Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
  • SUZUKI HAJIME
    New Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
  • OKURA AKIRA
    New Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
  • SUDA HIROYUKI
    New Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.

書誌事項

タイトル別名
  • I. FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

この論文をさがす

説明

New antitumor substance, designated BE-18591, was isolated from the culture broth of a streptomycete, strain BA18591. The active principle was extracted from mycelium by methanol and purified by silica gel chromatography. BE-18591 inhibited the growth of MKN-45 human stomach cancer cell line as well as P388 cell line. In in vivo experiments, BE-18591 inhibited the growth of Ehrlich ascites tumor.BE-18591 showed antimicrobial activity against Gram-positive and some Gram-negative bacteria.

収録刊行物

  • The Journal of Antibiotics

    The Journal of Antibiotics 46 (12), 1799-1803, 1993

    公益財団法人 日本感染症医薬品協会

詳細情報 詳細情報について

  • CRID
    1390001204149947392
  • NII論文ID
    130003502440
  • DOI
    10.7164/antibiotics.46.1799
  • COI
    1:CAS:528:DyaK2cXpsV2rsw%3D%3D
  • ISSN
    18811469
    00218820
  • PubMed
    8294236
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ