Ansamitocins, maytansinoid antitumor antibiotics producing organism, fermentation, and antimicrobial activities.

DOI Web Site PubMed 被引用文献1件
  • TANIDA SEIICHI
    Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
  • HASEGAWA TORU
    Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
  • HATANO KAZUNORI
    Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
  • HIGASHIDE EIJI
    Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
  • YONEDA MASAHIKO
    Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

書誌事項

タイトル別名
  • Ansamitocins Maytansinoid Antitumor Ant

この論文をさがす

抄録

Ansamitocins are new maytansinoid antitumor antibiotics produced by an actinomycete strain No. C-15003 (N-1). The organism is characterized by coremia formation on solid media, release of the rod-shaped motile spores with peritrichous flagella in liquid media, the formation of some branched mycelia at a later stage of growth in liquid culture which break up into motile elements, lysozyme resistance, the occurrence of meso-diaminopimelic acid in the cell wall, and guanine-cytosine content of 71±1 mol %. From these results, the organism has been designated as Nocardia sp. No. C-15003 (N-1). In the fermentation fluids, activity against eukaryotic microorganisms was detected. Three of the purified materials, which have the activity against Tetrahymena pyriformis strain W and Hamigera avellanea IFO 7721, were new ansamycin antibiotics with antileukemic activities and were named ansamitocins P-3, P-3' and P-4. Ansamitocins show growth inhibitory activity against several eukaryotic microorganisms but no activity against prokaryotic microorganisms. The acyl moieties at the C-3 position of ansamitocins are essential for their antifungal activities.

収録刊行物

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ