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- IWATA KAZUO
- Department of Microbiology, Meiji College of Pharmacy
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- YAMAMOTO YOSHINORI
- Department of Microbiology, Meiji College of Pharmacy
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- YAMAGUCHI HIDEYO
- Department of Microbiology, Faculty of Medicine, University of Tokyo
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- HIRATANI TAMIO
- Department of Microbiology, Faculty of Medicine, University of Tokyo
書誌事項
- タイトル別名
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- In vitro studies of aculeacin A, a new antifungal antibiotic.
- In Vitro Studies of Aculeacin A a New A
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説明
Aculeacin A is a cyclopeptide-containing long-chain fatty acid, representing a new class of antibiotics. It has a relatively narrow antifungal spectrum in vitro and is highly active against some groups of yeasts. Of 31 strains of Candida and Torulopsis tested, the majority were susceptible to aculeacin A at 0.31μg per ml or less. On the other hand, the antibiotic was scarcely active or inactive against other yeasts, such as Cryptococcus neoformans, and all filamentous and dimorphic fungi tested. A distinct inoculum effect has been observed in vitro with a number of strains of C. albicans; minimum growth-inhibitory concentrations (MIC) have tended to increase with increased incubation time. MIC values were also increased in the presence of serum. Aculeacin A is fungicidal for growing cells of C. albicans. It was most lethal against sensitive yeasts at 0.08 to 0.31μg per ml, and increases in the concentration of the drug above this range reduced, rather than increased, its lethal effect.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 35 (2), 203-209, 1982
公益財団法人 日本感染症医薬品協会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204150178432
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- NII論文ID
- 130003500212
- 40005315060
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaL38XhtFyqsro%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 2482049
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- PubMed
- 7042670
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可