Parvodicin, a novel glycopeptide from a new species, Actinomadura parvosata: Discovery, taxonomy, activity and structure elucidation.
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- CHRISTENSEN SIEGFRIED B.
- Research and Development Division, Smith Kline & French Laboratories
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- ALLAUDEEN H. S.
- Research and Development Division, Smith Kline & French Laboratories
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- BURKE MICHAEL R.
- Research and Development Division, Smith Kline & French Laboratories
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- CARR STEVEN A.
- Research and Development Division, Smith Kline & French Laboratories
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- CHUNG S. K.
- Research and Development Division, Smith Kline & French Laboratories
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- DEPHILLIPS PETER
- Research and Development Division, Smith Kline & French Laboratories
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- DINGERDISSEN JOHN J.
- Research and Development Division, Smith Kline & French Laboratories
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- DIPAOLO MICHAEL
- Research and Development Division, Smith Kline & French Laboratories
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- GIOVENELLA ALBERT J.
- Research and Development Division, Smith Kline & French Laboratories
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- HEALD SARAH L.
- Research and Development Division, Smith Kline & French Laboratories
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- KILLMER LEWIS B.
- Research and Development Division, Smith Kline & French Laboratories
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- MICO BRUCE A.
- Research and Development Division, Smith Kline & French Laboratories
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- MUELLER LUCIANO
- Research and Development Division, Smith Kline & French Laboratories
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- PAN CHARLES H.
- Research and Development Division, Smith Kline & French Laboratories
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- POEHLAND BENJAMIN L.
- Research and Development Division, Smith Kline & French Laboratories
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- RAKE JAMES B.
- Research and Development Division, Smith Kline & French Laboratories
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- ROBERTS GERALD D.
- Research and Development Division, Smith Kline & French Laboratories
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- SHEARER MARCIA C.
- Research and Development Division, Smith Kline & French Laboratories
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- SITRIN ROBERT D.
- Research and Development Division, Smith Kline & French Laboratories
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- NISBET Louis J.
- Research and Development Division, Smith Kline & French Laboratories
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- JEFFS PETER W.
- Research and Development Division, Smith Kline & French Laboratories
説明
An extensive taxonomic investigation identified strain SK&F-AAJ-271 as a new species, designated Actinomadura parvosata. Fermentations of this organism produce a complex of acidic, lipophilic glycopeptide antibiotics, the parvodicins. Structures for seven of the isolated components were derived from a combination of mass spectral, high-field NMR and chemical techniques. The O-acetyl functionality present in two of the isolated components is a structural feature unique among the known members of this class of antibiotics. The parvodicins are active in vitro against a range of Gram-positive bacteria. The most active parvodicin, C1, produces high serum levels in vivo and has the potential for a long duration of action.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 40 (7), 970-990, 1987
公益財団法人 日本感染症医薬品協会
