Epothilones A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties
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- GERTH KLAUS
- GBF, Gesellschaft fur Biotechnologische Forschung, Abteilung Naturstoffbiologie
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- BEDORF NORBERT
- Abteilung Naturstoffchemie
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- HÖFLE GERHARD
- Abteilung Naturstoffchemie
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- IRSCHIK HERBERT
- GBF, Gesellschaft fur Biotechnologische Forschung, Abteilung Naturstoffbiologie
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- REICHENBACH HANS
- GBF, Gesellschaft fur Biotechnologische Forschung, Abteilung Naturstoffbiologie
書誌事項
- タイトル別名
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- Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties.
- Production, Physico-chemical and Biological Properties
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説明
An antifungal activity against Mucor hiemalis was detected in the culture broth of Sorangium cellulosum (Myxococcales) strain So ce90. The activity was excreted into the supernatant during the log and early stationary phase. When the adsorber resin XAD-16 was added to the culture, the active metabolites were quantitatively bound to the resin. The epothilons showed a high cytotoxicity for animal cells and mimic the biological effects of taxol (BOLLAG et al., Cancer Res. 55: 2325-2333, 1995).
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 49 (6), 560-563, 1996
公益財団法人 日本感染症医薬品協会