Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov.. II. Isolation, physico-chemical characterization and biological activities of mycoplanecin A.

NAKAJIMA MUTSUO, TORIKATA AKIO, ICHIKAWA YOSHIKAZU, KATAYAMA TOSHIAKI, SHIRAISHI AKIO, HANEISHI TATSUO, ARAI MAMORU

doi:10.7164/antibiotics.36.961

Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov.. II. Isolation, physico-chemical characterization and biological activities of mycoplanecin A.

DOI PubMed

NAKAJIMA MUTSUO

Fermentation Research Laboratories, Sankyo Co., Ltd.
TORIKATA AKIO

Fermentation Research Laboratories, Sankyo Co., Ltd.
ICHIKAWA YOSHIKAZU

Fermentation Research Laboratories, Sankyo Co., Ltd.
KATAYAMA TOSHIAKI

Fermentation Research Laboratories, Sankyo Co., Ltd.
SHIRAISHI AKIO

Fermentation Research Laboratories, Sankyo Co., Ltd.
HANEISHI TATSUO

Fermentation Research Laboratories, Sankyo Co., Ltd.
ARAI MAMORU

Fermentation Research Laboratories, Sankyo Co., Ltd.

書誌事項

タイトル別名

II. ISOLATION, PHYSICO-CHEMICAL CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF MYCOPLANECIN A

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説明

New antibiotics, mycoplanecins, were found in the culture broth of an actinomycete identified as Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov. Mycoplanecin complex was extracted with organic solvents both from the culture filtrate and mycelium and purified by column chromatography on silica gel and Florisil. Mycoplanecin A, a major component, was separated by high performance liquid chromatography on Prep PAK-500/C₁₈ column. The physico-chemical characterization revealed that mycoplanecin A was a new cyclic peptide antibiotic. Mycoplanecins exhibited strong activities primarily against mycobacteria and related microorganisms.