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- NOTO TAKAO
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- MIYAKAWA SATOHIDE
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- OISHI HIDEO
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- ENDO HISAO
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- OKAZAKI HIROSHI
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
書誌事項
- タイトル別名
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- III. <i>IN VITRO</i> ANTIBACTERIAL ACTIVITY
この論文をさがす
説明
Thiolactomycin is a new broad-spectrum antibiotic, active in vitro against many species of Gram-positive cocci, Enterobacteriaceae, Haemophilus, acid-fast bacteria and anaerobic bacteria. However, the activity is generally moderate and bacteriostatic in action. This antibiotic eludes cross resistance with any of the known antibacterial drugs such as ampicill in, carbenicillin or cycloserine. The effect on Gram-negative bacilli in vitro is little affected by the inoculum size, the presence of horse serum, the pH of the medium or the type of medium. When thiolactomycin was added to the assay medium, the minimum inhibitory concentration of ampicillin against inducible β-lactamase producing strains of Staphylococcus aureus and Pseudonzonasa eruginosa was reduced. Thiolactomycin inhibited the production of inducible β-lactamase in several organisms.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 35 (4), 401-410, 1982
公益財団法人 日本感染症医薬品協会