Metabolic products of microorganisms. 244. Colabomycins, new antibiotics of the manumycin group from Streptomyces griseoflavus. I. Isolation, characterization and biological properties.
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- GROTE RALPH
- Institut für Organische Chemie, Universität Göttingen
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- ZEECK AXEL
- Institut für Organische Chemie, Universität Göttingen
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- DRAUTZ HANNELORE
- Institut für Biologic II, Universität Tübingen
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- ZÄHNER HANS
- Institut für Biologic II, Universität Tübingen
書誌事項
- タイトル別名
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- I. ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES
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説明
The yellow colabomycins A to C, three new antibiotics of the manumycin group produced by Streptomyces griseoflavus (strain Tü 2880), were detected by chemical screening. They were isolated from mycelium extracts by column chromatography on various adsorbents, followed by preparative reversed phase HPLC. The main compound, colabomycin A (1), was characterized and shown to be chiefly biologically active against Gram-positive bacteria and stem cells of murine L1210 leukemia.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 41 (9), 1178-1185, 1988
公益財団法人 日本感染症医薬品協会