FR901277, a novel inhibitor of human leukocyte elastase from Streptomyces resistomycificus. Producing organism, fermentation, isolation, physico-chemical and biological properties.

書誌事項

タイトル別名
  • PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

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説明

A novel human leukocyte elastase inhibitor, FR901277 was discovered in the fermentation broth of Streptomyces resistomycificus No. 7622. FR901277 has a molecular weight of 961 and a molecular formula of C47H63N9O13. The mode of inhibition is competitive, with a Ki of 1.2×10-8M. Oral administration of FR901277 at doses from 32 to 320mg/kg significantly prevented human leukocyte elastase-induced foot edema in mice.

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詳細情報 詳細情報について

  • CRID
    1390001204151264896
  • NII論文ID
    130003502562
  • DOI
    10.7164/antibiotics.46.908
  • COI
    1:CAS:528:DyaK3sXlslOhu7k%3D
  • ISSN
    18811469
    00218820
  • PubMed
    8344871
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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