FR901277, a novel inhibitor of human leukocyte elastase from Streptomyces resistomycificus. Producing organism, fermentation, isolation, physico-chemical and biological properties.
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- FUJIE KEIKO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- SHINGUH YASUHIKO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- HATANAKA HIROSHI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- SHIGEMATSU NOBUHARU
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- MURAI HLDETSUGU
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- FUJITA TAKASHI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- YAMASHITA MLCHIO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- OKAMOTO MASANORI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- OKUHARA MASAKUNI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
書誌事項
- タイトル別名
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- PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
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説明
A novel human leukocyte elastase inhibitor, FR901277 was discovered in the fermentation broth of Streptomyces resistomycificus No. 7622. FR901277 has a molecular weight of 961 and a molecular formula of C47H63N9O13. The mode of inhibition is competitive, with a Ki of 1.2×10-8M. Oral administration of FR901277 at doses from 32 to 320mg/kg significantly prevented human leukocyte elastase-induced foot edema in mice.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 46 (6), 908-913, 1993
公益財団法人 日本感染症医薬品協会