Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
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- TAKAHASHI ATSUSHI
- Institute of Microbial Chemistry
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- KURASAWA SHOGO
- Institute of Microbial Chemistry
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- IKEDA DAISHIRO
- Institute of Microbial Chemistry
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- OKAMI YOSHIRO
- Institute of Microbial Chemistry
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
書誌事項
- タイトル別名
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- I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
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説明
Screening of new insecticidal and acaricidal antibiotics was carried out with reference to anti-brine shrimp activity from actinomycete strains isolated from marine environments. Of 200 actinomycete isolates, one isolate was found to produce a new substance, altemicidin. The strain was isolated from sea mud collected at Gamo, Miyagi Prefecture, Japan, and identified as Streptomyces sioyaensis SA-1758.<br> Altemicidin was purified by Diaion CHP-20P and Sephadex LH-20 column chromatographies. The molecular formula was determined as C13H20N4O7S by elemental analysis, MS and 13C NMR spectrum.<br> Altemicidin showed not only acaricidal activity but also antitumor activity. The compound showed no antimicrobial activity except the inhibitory activity to Xanthomonas strains.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 42 (11), 1556-1561, 1989
公益財団法人 日本感染症医薬品協会