Microbial Conversion of Milbemycins: Oxidation of Milbemycin A4 and Related Compounds at the C-25 Ethyl Group by Circinella umbellata and Absidia cylindrospora.
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- NAKAGAWA KEIKO
- Biomedical Research Laboratories, Sankyo Co., Ltd.
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- TSUKAMOTO YOSHIHISA
- Agroscience Research Laboratories, Sankyo Co., Ltd.
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- SATO KAZUO
- Agroscience Research Laboratories, Sankyo Co., Ltd.
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- TORIKATA AKIO
- Biomedical Research Laboratories, Sankyo Co., Ltd.
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説明
Microbial oxidation of milbemycin A4 at the C-25 ethyl group was performed. Milbemycin A4 was converted to 31- and 32-hydroxy derivatives by Cirdnella umbellata SANK 44272 along with 24- and 30-hydroxy derivatives. Related compounds, 5-ketomilbemycin A4 5-oxime and 13β-fluoromilbemycin A4 were similarly converted to the hydroxylated compounds by this microorganism. Absidia cylindrospora SANK 31472 converted milbemycin A4 to the corresponding 32-oic acid, 24-hydroxy derivative and a few oxygenated compounds including at the C-25 ethyl group.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 48 (8), 831-837, 1995
公益財団法人 日本感染症医薬品協会