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- NAGATSU TOSHIHARU
- Department of Biochemistry, School of Dentistry, Aichi-Gakuin University
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- AYUKAWA SABURO
- Institute of Microbial Chemistry
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- UMEZAWA HAMAO
- Institute of Microbial Chemistry
書誌事項
- タイトル別名
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- Inhibition of dopamine ベータ-hydroxylase by aquayamycin
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抄録
Aquayamycin was found to be one of the most potent inhibitors of dopamine β-hydroxylase. Aquayamycin at 4×10-7 M inhibited the enzyme by 50% with a Ki value of 2.1×10-7 M. The inhibitionwas non-competitive with substrate and was not affected by cof actors, i.e. ascorbic acid or fumarate. The inhibitory mechanism is possibly due to chelating action of aquayamycin on protein-bound copper. However, the addition of Cu++ did not reverse the inhibition.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 21 (5), 354-357, 1968
公益財団法人 日本感染症医薬品協会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204152361472
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- NII論文ID
- 130003498097
- 40018688253
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaF1MXhslaiuw%3D%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 8509909
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- PubMed
- 5726289
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可