MEGALOMICIN, A NEW MACROLIDE ANTIBIOTIC COMPLEX PRODUCED BY <i>MICROMONOSPORA</i>
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- WEINSTEIN MARVIN J.
- Department of Microbiology, Schering Corporation
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- WAGMAN GERALD H.
- Department of Microbiology, Schering Corporation
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- MARQUEZ Joseph A.
- Department of Microbiology, Schering Corporation
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- TESTA RAYMOND T.
- Department of Microbiology, Schering Corporation
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- ODEN EDWIN
- Department of Microbiology, Schering Corporation
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- WAITZ J. ALLAN
- Department of Microbiology, Schering Corporation
Bibliographic Information
- Other Title
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- Megalomicin,a new macrolide antibiotic complex produced by Micromonospora
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Abstract
A new macrolide antibiotic complex has been isolated from fermentation broths of two strains of a news pecies of Micromonospora, M. megalomicea sp. n. The antibiotic complex has been differentiated from other known macrolides and methods for its production, isolation and separation of components have been devised. Like other macrolides, it is primarily active against gram-positive bacteria and is more active at an alkaline pH. Of the four known components, megalomicin A has been studied most extensively. It has activity equal to or slightly less than that of erythromycin both in vitro and in vivo. In dogs dosed orally, it is better tolerated and gives higher peak serum levels with a much greater duration than erythromycin.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 22 (6), 253-258, 1969
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Details 詳細情報について
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- CRID
- 1390001204152559616
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- NII Article ID
- 40018688401
- 130003498193
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- NII Book ID
- AA0069330X
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- COI
- 1:CAS:528:DyaF1MXktlOgtbw%3D
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- ISSN
- 18811469
- 00218820
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- NDL BIB ID
- 8510057
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- PubMed
- 5810991
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed