Kuwaitimycin, effect on synthesis of lipids in Bacillus subtilis cells.

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  • SHIMI IBRAHIM R.
    Faculty of Science, Ain Shams University, Biochemistry Department
  • SHOUKRY SAFWAT
    Faculty of Science, Ain Shams University, Biochemistry Department
  • ZAKI ZEINAB
    Faculty of Science, Ain Shams University, Biochemistry Department

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  • Kuwaitimycin effect on synthesis of lip

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The effects exerted by kuwaitimycin on synthesis of lipids as well as some metabolic activities of Bacillus subtilis were studied. The antibiotic not only arrested the incorporation of 14C-acetate into the microbial lipids but also altered the fatty acids pattern, contents of i-C 15, a-C 15, i-C 17 and a-C 17 were markedly reduced, concomitant with an increase in the contents of i-C 14 and n-C 14. Moreover, the rates of synthesis of phospholipids were decreased by the drug, especially that of phosphatidyl ethanolamine.

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