STUDIES ON THE EFFECT OF TETRACYCLINE ON TRIGLYCERIDE SYNTHESIS IN EXPERIMENTAL RATS

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Abstract

1. Triglyceride synthesis in rat liver homogenate is stimulated by administration of a single therapeutic dose of tetracycline to the animal prior to sacrifice and maximum stimulation is observed 3 hours after drug-treatment.<br> 2. In the intact tetracycline-treated rat, incorporation of injected 1-14C-palmitate into liver triglyceride reaches its maximum 3 hours after the drug administration.<br> 3. The release of newly synthesized triglyceride from liver to the circulation system seems to be impaired under the influence of the antibiotic treatment.<br> 4. Tetracycline is unable to stimulate triglyceride synthesis in liver homogenate obtained from adrenalectomized rats treated with this antibiotic.

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