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- NOSE MASAKO
- Department of Agricultural Chemistry, the University of Tokyo
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- ARIMA KEI
- Department of Agricultural Chemistry, the University of Tokyo
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Pyrrolnitrin inhibits the syntheses of protein, RNA and DNA to almost the same degree. It also inhibits respiration but this site does not seem to be the primary action. It does not inhibit the biosynthesis of porphyrin. It is not an uncoupler of oxidative phosphorylation. It inhibits the transport of many substances, and causes the leakage of A260mμ absorbing materials inside the cells. Pyrrolnitrin bursts the protoplasts of Bacillus megaterium KM strain at the growth inhibitory concentration. This action is completely neutralized by an approximately equimolar concentration of some phospholipids in the cell membrane components. It is concluded that the primary damage by pyrrolnitrin occurs in the cell membrane through a combination of pyrrolnitrin and some phospholipids.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 22 (4), 135-143, 1969
公益財団法人 日本感染症医薬品協会
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詳細情報 詳細情報について
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- CRID
- 1390001204152871424
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- NII論文ID
- 130003498169
- 40018688374
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaF1MXktFSlsb4%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 8510030
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可