ON THE MODE OF ACTION OF A NEW ANTIFUNGAL ANTIBIOTIC, PYRROLNITRIN

DOI Web Site
  • NOSE MASAKO
    Department of Agricultural Chemistry, the University of Tokyo
  • ARIMA KEI
    Department of Agricultural Chemistry, the University of Tokyo

この論文をさがす

抄録

Pyrrolnitrin inhibits the syntheses of protein, RNA and DNA to almost the same degree. It also inhibits respiration but this site does not seem to be the primary action. It does not inhibit the biosynthesis of porphyrin. It is not an uncoupler of oxidative phosphorylation. It inhibits the transport of many substances, and causes the leakage of A260mμ absorbing materials inside the cells. Pyrrolnitrin bursts the protoplasts of Bacillus megaterium KM strain at the growth inhibitory concentration. This action is completely neutralized by an approximately equimolar concentration of some phospholipids in the cell membrane components. It is concluded that the primary damage by pyrrolnitrin occurs in the cell membrane through a combination of pyrrolnitrin and some phospholipids.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ