Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein. IV. In vitro synergism between neoviridogrisein II and the antibiotics of the mikamycin A group.
-
- OKUMURA YASUSHI
- Central Research Laboratories, Sanraku-Ocean Co., Ltd.
-
- SAKAMOTO MICHIKO
- Central Research Laboratories, Sanraku-Ocean Co., Ltd.
-
- TAKEI TOMOKO
- Central Research Laboratories, Sanraku-Ocean Co., Ltd.
-
- ISHIKURA TOMOYUKI
- Central Research Laboratories, Sanraku-Ocean Co., Ltd.
-
- FUKAGAWA YASUO
- Central Research Laboratories, Sanraku-Ocean Co., Ltd.
書誌事項
- タイトル別名
-
- IV. <i>IN VITRO</i> SYNERGISM BETWEEN NEOVIRIDOGRISEIN II AND THE ANTIBIOTICS OF THE MIKAMYCIN A GROUP
この論文をさがす
説明
Neoviridogrisein II is a homologue of viridogriscin in which the hydroxyproline residue is replaced by proline. Neoviridogrisein II proved to be more active than the parent antibiotic against Gram-positive bacteria and Mycoplasma species. When neoviridogrisein II or viridogrisein was combined with griseoviridin, a non-peptidyl macrocyclic lactone, synergism was observed: maximum synergistic effect was observed for a combination ratio that depended on the test bacterium used. Neoviridogrisein II also exerted synergism when combined with mikamycin A and A-2315A.
収録刊行物
-
- The Journal of Antibiotics
-
The Journal of Antibiotics 32 (11), 1130-1136, 1979
公益財団法人 日本感染症医薬品協会