ANTI-MICROBIAL ACTIVITIES OF ENDURACIDIN (ENRAMYCIN) <i>IN VITRO</i> AND <i>IN VIVO</i>

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  • KAWAKAMI MASAYA
    Department of Microbiology, School of Medicine, Gunma University
  • NAGAI YUTAKA
    Department of Microbiology, School of Medicine, Gunma University
  • FUJII TOSHIO
    Department of Microbiology, School of Medicine, Gunma University
  • MITSUHASHI SUSUMU
    Department of Microbiology, School of Medicine, Gunma University

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  • Anti-microbial activities of enduracidin(enramycin)in vitro and in vivo

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Abstract

Enduracidin (enramycin) was found to have high order of antibacterial activity against various antibiotic-resistant strains of staphylococci, and to be free of cross-resistance with antibiotics commercially available at present. This drug was proved to be ineffective against dysentery bacillus and other gram-negative bacilli. It is believed to be an agent to which bacterial resistance hardly increases. The 50% effective dose (ED50) of enramycin in experimental Staphylococcus aureus infections in mice was proved to be 2.27 mg/kg.

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