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- NUNN ADRIAN D.
- Medical Research Council, Cyclotron Unit, Hammersmith Hospital
Bibliographic Information
- Other Title
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- Interactions between bleomycins and met
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Description
Gel filtration has shown that there are considerable differences between the metal complexes of bleomycin A2 and B2 with indium, cobalt or copper. Differences in the rates of formation of the complexes have also been found and it is thought that these effects are due to a difference<br>in co-ordination between the metals and the bleomycin. The co-ordination changes are thought to be the cause of the differences in in vivo distribution of metal bleomycin complexes found in the radiodiagnosis of tumours. The ease of formation of the copper or cobalt complexes is suggested as a possible mechanism for the inhibition of the attack of DNA by bleomycins.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 29 (10), 1102-1108, 1976
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390001204154147072
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- NII Article ID
- 130003499125
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- NII Book ID
- AA0069330X
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- COI
- 1:CAS:528:DyaE28XlvVagtrs%3D
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- ISSN
- 18811469
- 00218820
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- NDL BIB ID
- 1731261
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- PubMed
- 62856
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed