In vitro studies with cefazaflur and other parenteral cephalosporins.

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  • ACTOR PAUL
    Research and Development Division Smith Kline & French Laboratories
  • GUARINI JOSEPH R.
    Research and Development Division Smith Kline & French Laboratories
  • URI JOSEPH
    Research and Development Division Smith Kline & French Laboratories
  • BARTUS HENRY F.
    Research and Development Division Smith Kline & French Laboratories
  • ZAJAC IHOR
    Research and Development Division Smith Kline & French Laboratories
  • WEISBACH JERRY A.
    Research and Development Division Smith Kline & French Laboratories

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  • In vitro studies with cefazaflur and ot

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Cefazaflur has a broad-spectrum of in vitro antibacterial activity equal to or greater than that of the commercially-available cephalosporins. In addition, cefazaflur has activity against isolates of Enterobacter, Citrobacter and indole-positive Proteus; however, this activity decreased markedly when the MIC determinations were carried out with a large inoculum size. A similar inoculum effect was observed with cefamandole, however, cefoxitin's activity was relatively unchanged at increased inoculum sizes. Human serum had a relatively small effect on the in vitro activity of cefazaflur.

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