NOCARDICIN A, A NEW MONOCYCLIC β-LACTAM ANTIBIOTIC. III

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  • <i>IN VITRO</i> EVALUATION

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説明

Nocardicin A, a new monocyclic β-lactam antibiotic, exerts a comparatively potent antimicrobial activity against gram-negative organisms, especiallyPseudomonas aeruginosa, the indole-positive and indole-negativeProteusgroups (exceptPr. morganii), Serratia marcescens and theNeisseria groups. The in vitroantimicrobial activity of nocardicin A against clinical isolates ofPs. aeruginosa was about twice that of carbenicillin. The mean MICs of nocardicin A forPr. mirabilis, Pr. rettgeri and Pr. inconstans ranged from 3.13 to 12.5 μg/ml and were 25-50 μg/ml forPr. vulgaris. Nocardicin A in concentrations of 12.5-50 μg/ml inhibited 30 strains (48%) ofS. inarcescens usually resistant to β-lactam antibiotics. However, nocardicin A had no significantin vitro activity againstStaphylococci andEscherichia coli. No cross-resistance was seen between nocardicin A and other β-lactam antibiotics. This antibiotic was stable to β-lactamase. Thein vitroactivity of nocardicin A againstPs. aeruginosa andPr. mirabilis was greatly influenced by the assay media used. Nocardicin A was bactericidal and appeared to act synergistically with serum bactericidal factors against Ps. aeruginosa and with polymorphonuclear leukocytes againstPs. aeruginosa, E. coli and Pr. vulgaris. The bactericidal activity of nocardicin A against the above 3 organisms, therefore, increased markedly in the presence of fresh serum and polymorphonuclear leukocytes.

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詳細情報 詳細情報について

  • CRID
    1390001204155006080
  • NII論文ID
    130003499300
  • DOI
    10.7164/antibiotics.30.917
  • COI
    1:CAS:528:DyaE1cXlvVymsg%3D%3D
  • ISSN
    18811469
    00218820
  • PubMed
    412823
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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