Intracellular reduction of the cupric ion of bleomycin copper complex and transfer of the cuprous ion to a cellular protein.

DOI Web Site PubMed

書誌事項

タイトル別名
  • Intracellular reduction of the cupric i

この論文をさがす

抄録

The cupric ion of the bleomycin copper complex has been shown to be reduced and transferred to a cellular protein by the following mechanism: Bleomycin-Cu2+→Bleomycin+Cu+ X Cu++M→M-Cu+ The intracellular reducing agents (X) are suggested to be sulfhydryl compounds, because their action is inhibited by N-ethylmaleimide. The active group of the cellular protein (M) that binds with the cuprous ion is suggested to be a sulfhydryl group. The action of the bleomycin copper complex in causing DNA fragmentation in cells can be explained by the mechanism presented in this paper. This mechanism in cells is also supported by the temperature dependency of the action of the bleomycin copper complex on cells.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ