Development of 192Ir sources for brachytherapy.

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  • KATO Hisashi
    Division of Radioisotope Production, Radioisotope Center, Japan Atomic Energy Research Institute
  • KOGURE Hiroto
    Division of Radioisotope Production, Radioisotope Center, Japan Atomic Energy Research Institute
  • TAKEUCHI Norio
    Division of Radioisotope Production, Radioisotope Center, Japan Atomic Energy Research Institute
  • KOBAYASHI Katsutoshi
    Division of Radioisotope Production, Radioisotope Center, Japan Atomic Energy Research Institute
  • SUZUKI Kyohei
    Division of Radioisotope Production, Radioisotope Center, Japan Atomic Energy Research Institute
  • SHIKATA Eizi
    Division of Radioisotope Production, Radioisotope Center, Japan Atomic Energy Research Institute

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Other Title
  • 医療用<SUP>192</SUP>Ir小線源の開発
  • 医療用192Ir小線源の開発〔英文〕
  • イリョウヨウ192Ir ショウ センゲン ノ カイハツ エイブン

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Abstract

Techniques for the production of three kinds of 192Ir sources, i.e. hairpin, single-pin and seed, for brachytherapy were developed in Japan Atomic Energy Research Institute. Platinum-iridium alloy wire sheathed with platinum tube in advance were irradiated by the JRR-2 or JRR-3 reactor. The platinum tube cuts of beta-rays so as to minimize unnecessary radiation exposure to patients. Irradiation conditions were determined to obtain the radioactivity of 0.74 GBq (20 mCi) for a hairpin, 0.37 GBq (10 mCi) for a single-pin and 0.37×10-1 GBq (1 mCi) for a seed, respectively, at the end of irradiation. Fluctuation in the linear distribution of the radioactivity along the hairpin source or the single-pin source was small enough on the viewpoint of its application. No significant impurity or surface contamination was observed in the source produced with pre-encapsulation. Seed targets were loaded in a polyethylene tube so as to be suitable for the new treatment technique of tumor. Irradiation of seed targets, packed alternately with nylon spacers in a polyethylene tube, was found to be satisfactory for preparing ribbon sources.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 29 (9), 427-431, 1980

    Japan Radioisotope Association

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