-
- WAGNER EUGENE S.
- Department of Chemistry, Ball State University
-
- LINDLEY BARRY
- Department of Chemistry, Ball State University
-
- TALBERT MADONNA
- Department of Chemistry, Ball State University
書誌事項
- タイトル別名
-
- Benzylpenicillin Migrates Irreversibly
この論文をさがす
抄録
Benzylpenicillin, 5.2% 14C-enriched, was incubated with human whole blood. The erythrocyte component was washed and exhaustively dialyzed and found to contain 6.3% of the original radioactivity. None of the penicillin was found to bind to the cell membrane. Dialysis of the cell contents indicated that none of the penicillin binds irreversibly to the proteins within the cell. Infrared examination of the contents of the cell leads to the<br>conclusion that benzylpenicillin (a monovalent anion) enters the erythrocyte and is hydrolyzed to benzylpenicilloic acid (a divalent anion). This structural change prevents the antibiotic from migrating out of the cell.
収録刊行物
-
- The Journal of Antibiotics
-
The Journal of Antibiotics 30 (12), 1115-1118, 1977
公益財団法人 日本感染症医薬品協会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204155253248
-
- NII論文ID
- 130003499327
- 40005313728
-
- NII書誌ID
- AA0069330X
-
- ISSN
- 18811469
- 00218820
-
- NDL書誌ID
- 1916985
-
- PubMed
- 599085
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可