Fortimicin a production by Micromonospora olivoasterospora in a chemically defined medium.
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- YAMAMOTO MITSUYOSHI
- Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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- OKACHI RYO
- Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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- KAWAMOTO ISAO
- Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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- NARA TAKASHI
- Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
書誌事項
- タイトル別名
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- Fortimicin A Production by Micromonospo
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A chemically defined medium was devised in order to study the requirements for fortimicin A production by Micromonospora olivoasterospora KY 11515. Soluble starch was the best carbon source; NH4Cl and NH4NO3 were suitable nitrogen sources both for the growth and fortimicin production. Amino acids such as L-arginine, L-asparagine, L-aspartic acid and L-glutamic acid showed some stimulatory effects on both growth and antibiotic production of <i>M. olivoasterospora</sup> while L-serine stimulated only antibiotic production and L-citrulline only the growth. K2HPO4, MgSO4•7H2O and CaCO3 were essential especially for the antibiotic production. The most important finding was that vitamin B12, cobalt and nickel showed marked stimulatory effects on fortimicin A production.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 30 (12), 1064-1072, 1977
公益財団法人 日本感染症医薬品協会
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詳細情報 詳細情報について
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- CRID
- 1390001204155255424
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- NII論文ID
- 130003499320
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaE1cXnt12huw%3D%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 1916991
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- PubMed
- 599081
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可