.BETA.-Lactamase and .BETA.-lactam antibiotics resistance in Acinetobacter anitratum (syn.: A. Calcoaceticus).

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  • β-lactamase and β-lactam antibiotics resistance in Acinetobacter antiratum(SYN.:A.calcoaceticus)
  • ベータ lactamase and ベータ lactam antibiotic

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Abstract

The cephalosporin β-lactamase (cephalosporinase) produced by Acinetobacter was studied. The enzyme was partially purified by means of column chromatography and its properties were investigated. The enzyme was induced by benzylpenicillin, 6-aminopenicillanic acid and cephaloridine. Its molecular weight is 30, 000, its optimal temperature 40°C, and its optimal pH 7.25-7.50. Substrate specificity studies using various cephalosporins and penicillins, showed that the enzyme functioned as a cephalosporinase rather than penicillinase.

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