Synthesis of carbon-14 and tritium labeled sagamicin.

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  • DEGUCHI TAKASHI
    Pharmaceuticals Research Laboratory, Kyowa Hakko Co., Ltd.
  • OKUMURA SHUZO
    Pharmaceuticals Research Laboratory, Kyowa Hakko Co., Ltd.
  • ISHII AKIO
    Pharmaceuticals Research Laboratory, Kyowa Hakko Co., Ltd.
  • TANAKA MASAO
    Pharmaceuticals Research Laboratory, Kyowa Hakko Co., Ltd.

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  • Synthesis of carbon 14 and tritium labe

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Sagamicin, an aminoglycoside antibiotic, was labeled with tritium by means of a platinum catalyzed hydrogen exchange reaction and by carbon-14 in two biosynthetic procedures. 14C-Methyl-L-methionine was used as the radioactive precursor in these biological processes involving Micromonospora sagamiensis. The distribution of radioactivity in 14C-sagamicin and gentamicin C1 was studied by mild acid hydrolysis and HOFMANN degradation. The results showed that both C- and N-methyl groups were derived from methionine. One of<br>the biosynthetic processes involved the conversion of gentamicin into sagamicin with resting cells and labeled methionine.

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