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- MILLER A. KATHRINE
- Merck Institute for Therapeutic Research
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- CELOZZI EVEMARIE
- Merck Institute for Therapeutic Research
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- PELAK BARBARA ANN
- Merck Institute for Therapeutic Research
書誌事項
- タイトル別名
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- The enhancement of .BETA.-lactam antibiotic therapy by novobiocin.
- enhancement of ベータ lactam antibiotic th
この論文をさがす
抄録
Novobiocin demonstrates an effect similar to that of probenecid (the "probenecid effect") in enhancing the therapeutic efficacy of antibiotics excreted mainly by the renal tubules. The ability of cefoxitin, cephalexin, cephalothin and penicillin G to protect mice against infection with Salmonella schottmuelleri was enhanced 2- to 3-fold when the animals were given oral doses of either probenecid or of novobiocin. The efficacy of cephaloridine, excreted mainly by glomerular filtration, was not enhanced by either probenecid or by novobiocin.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 30 (11), 983-986, 1977
公益財団法人 日本感染症医薬品協会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204155295616
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- NII論文ID
- 130003499310
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- NII書誌ID
- AA0069330X
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 1914733
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- PubMed
- 591464
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可