Study of Affinity for a Malignant Tumor and Organs of the Elements in Group ll of the Periodic Table
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- ANDO Atsushi
- Radiation Technician School Affiliated with Kanazawa University
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- HISADA Kin-ichi
- Dept. of Nuclear Medicine, School of Med., Kanazawa University
Bibliographic Information
- Other Title
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- 周期律第II族元素のがんおよび臓器親和性の研究
- シュウキ リツ ダイ2ゾク ゲンソ ノ ガン オヨビ ゾウキ シンワセイ ノ ケンキュウ
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Description
Seven preparations, 115mCd-chloride, 115mCd-citrate, 115mCd-EDTA, 65Zn-chloride, 85Sr-chloride, 85Sr-citrate and 85Sr-EDTA were injected intravenously to each group of rats transplanted subcutaneously with Yoshida sarcoma. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in 115mCd-chloride and 115mCd-citrate, 3 hours and 24 hours in 115mCd-EDTA and 65Zn-chloride, 15 minutes, 3 hours and 24 hours in 85Sr-citrate, 15 minutes and 24 hours in 85Sr-chloride and 85Sr-EDTA. The radioactivities of tumor, blood, muscle, liver, kidney, pancreas and spleen were measured by a well-type scintillation counter, and retention values in every tissue including tumor were calculated (in per cent of administered dose per g-tissue weight) .<BR>115mCd-chloride, 115mCd-citrate and 65Zn-chloride had very strong affinity for the liver and considerably strong affinity for the pancreas and kidney. 115mCd-EDTA had considerably strong affinity for the kidney and liver, but had not affinity for the iancreas. 115mCd- and 65Zn-compounds had little affinity for the malignant tumor. 85Sr-compounds were rapidly cleared from these organs, but clearance of 85Sr-compounds in tumor were slower than the other organs.<BR>Cd, Zn and Sr (the elements in group II of the periodic table) had little affinity for the malignant tumor.
Journal
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- RADIOISOTOPES
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RADIOISOTOPES 20 (6), 273-278, 1971
Japan Radioisotope Association
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Details 詳細情報について
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- CRID
- 1390001204156112512
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- NII Article ID
- 130004380263
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- NII Book ID
- AN00351589
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- ISSN
- 18844111
- 00338303
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- NDL BIB ID
- 8103447
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed