Affinity for a Malignant Tumor and Organs at the Elements in Group VI of the Periodic Table

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  • ANDO Atsushi
    School of Paramedicine, School of Medicine, Kanazawa University
  • HISADA Kinichi
    Dept. of Nuclear Medicine, School of Medicine, Kanazawa University
  • ANDO Itsuko
    Dept. of Nuclear Medicine, School of Medicine, Kanazawa University

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Other Title
  • 周期律第VI族元素のがんおよび臓器親和性
  • シュウキリツ ダイ 6ゾク ゲンソ ノ ガン オヨビ ゾウキ シンワセイ

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Abstract

In order to investigate the tumor affinity radioisotopes, chromium (51Cr), molybdenum (99Mo), tungsten (181W), selenium (75Se) and tellurium (127mTe) -the elements of group VI in the periodic table-were examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma. Seven preparations, sodium chromate (Na251CrO4), chromium chloride (51CrCl3), normal ammonium molybdate ( (NH4) 299MoO4), sodium tungstate (Na2181WO4), sodium selenate (Na275SeO4), sodium selenite (Na275SeO3) and tellurous acid (H2127mTeO3) were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations. The radioaetivities of the tumor, blood, muscle, liver, kidney and spleen were measured by a well-type scintillation counter, and retention values (in every tissue including the tumor) were calculated in percent of administered dose per g-tissue weight.<BR>All of seven preparations did not have any affinity for malignant tumor. Na251CrO4 and H2127mTeO3 had some affinity for the kidneys, and Na275SeO3 had some affinity for the liver. Na2181WO4 and (NH4) 299MoO4 disappeared very rapidly from the blood and soft tissue, and about seventy-five percent of radioactivity was excreted in urine within first 3 hours.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 25 (10), 630-636, 1976

    Japan Radioisotope Association

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