周期律第III族元素のがん親和性の研究

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  • Studies on Affinity of the Element in Group III in the Periodic Table for Malignant Tumor
  • シュウキ リツ ダイ3ゾク ゲンソ ノ ガン シンワセイ ノ ケンキュウ

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67Ga-citrate is used for the clinical scanning of the malignant tumor, and affinity of 111In-chloride for the malignant tumor is reported by W.H. Hunter, et al. But the mechanism of their affinity for tumor is unknown. In order to investigate the mechanism of the accumulation of these elements in tumor, affinity for the malignant tumor of radioactive gallium, indium and scandium (the elements of group III in the periodic table) were examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma.<BR>In this experiment, several kinds of compound of gallium and indium had strong affinity for the malignant tumor, but scandium compounds had not affinity for the malignant tumor. These compounds which had strong affinity for the malignant tumor were those which were under carrier free state and became gallium-ion or indium-ion easily in the body.<BR>Gallium compounds containing little carrier had still strong affinity for tumor but indium compounds with carrier had not affinity for tumor even if amount of carrier was small. Gallium compounds and indium compounds suitable for the selective uptake by the malignant tumor have very strong affinities to the malignant tumor and their retention values in the tumor showed approximately the same, but the retention values in the blood and kidney were larger in indium than in gallium.<BR>From these experimental results, it is thought that gallium is more excellent for tumor detection than indium.

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