Studies on the Quality and Test Method of Radiopharmaceuticals (3)

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  • URAKUBO Goro
    Department of Radiochemistry, National Institute of Hygienic Sciences
  • TANAKA Akira
    Department of Radiochemistry, National Institute of Hygienic Sciences
  • HASEGAWA Akira
    Department of Radiochemistry, National Institute of Hygienic Sciences
  • IKEBUCHI Hideharu
    Department of Radiochemistry, National Institute of Hygienic Sciences

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Other Title
  • 放射性医薬品の品質および試験法に関する研究 (第3報)
  • ホウシャセイ イヤクヒン ノ ヒンシツ オヨビ シケンホウ ニ カンスル ケンキュウ 3 エンカ セシウム-131Cs ムキン ヨウエキ , エンカ ルビジウム-86Rb ムキン ヨウエキ , ヨウカ アンチピリン-131I ムキン ヨウエキ , クロルメロドリン-197Hg チュウシャエキ , メリソプロール-203Hg チュウシャエキ , ヨウカ ダイ ギョウシュウ ヒトケッセイ アルブミン-131I チュウシャエキ , オヨビ カテクネチウムサン ナトリウム-99mTc チュウシャエキ ノ ジュンド シケン ニ ツイテ
  • Purity Test of Cesium Chloride-<SUP>131</SUP>Cs Sterile Solution, Rubidium Chloride-<SUP>86</SUP>Rb Sterile Solution, lodoantipyrin-<SUP>131</SUP>I Sterile Solution, Chlormerodrin-<SUP>197</SUP>Hg
  • 塩化セシウム-<SUP>131</SUP>Cs無菌溶液, 塩化ルビジウム-<SUP>86</SUP>Rb無菌溶液, ヨウ化アンチピリン-<SUP>131</SUP>I無菌溶液, クロルメロドリン-<SUP>197</SUP>Hg注射液, メリソプロール-<SUP>203</SUP>Hg

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Abstract

Purity test of seven kinds of radiopharmaceuticals was examined by using paper and thin-layer chromatographic techniques and paper electrophoretic method. On paper chromatography, the most suitable solvents were shown as below;<BR>for cesium chloride and rubidium chloride: acetone/HCl/aq. dist.=4: 1: 3<BR>for chlormerodrin: dimethylformamide/aq. dist./methanol=5: 1: 14<BR>for merisoprol and sodium pertechnetate: 70% methanol.<BR>In the case of iodoantipyrin, paper chromatography was not suitable, but only thinlayer chromatography gave satisfactory result with a mixture of ethanol-benzene=2: 1.<BR>Electrophoresis with veronal buffer solution have proved most useful in the separation of macro aggregated human serum albumin and human serum albumin. The latter traveled further than the former which remained on the spotted origin under the same condition.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 20 (4), 180-184, 1971

    Japan Radioisotope Association

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