Evaluation of Stat Assay of Serum Digoxin Concentration by Radioimmunoassay and Its Application for Digoxin Regimen Based on Pharmacokinetics

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  • ラジオイムノアッセイによる血清ジゴキシン濃度の測定
  • ラジオイムノアッセイ ニヨル ケッセイ ジゴキシン ノウド ノ ソクテイ ジン
  • ―迅速測定法の検討と薬物動態理論に基づく治療設計への応用―

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Abstract

Serum digoxin concentrations measured by stat RIA (phadebas digoxin RIA kit) correlated well with results obtained by complete assays. The result of stat assay can be reported within 1 hour, measuring one or more samples together with 2 standard samples in duplicates. Precise measurement can be expected with serum digoxin concentration over 0.5 ng/ml.<BR>The stat assay allows to apply the theory of pharmacokinetics for the estimation of digoxin concentration at steady states measuring minimum digoxin concentration (Cn (min) ) on the 3rd to 6th day after the start of digoxin therapy. The estimated serum digoxin levels were well agreed with measured values with the difference ranging from Y.6 to 8.6% in CV.<BR>The method is usefull for the planning and assessment of appropriate digoxin regimen.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 29 (9), 432-437, 1980

    Japan Radioisotope Association

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