Syntheses of <SUP>14</SUP>C, <SUP>3</SUP>H Double Labeled Propargyl Aryl Ethers and Propargyl Aryl Carbinol

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  • <SUP>14</SUP>C, <SUP>3</SUP>H-2重標識プロパルギルアリルエーテル類およびプロパルアリルカービノールの合成

Abstract

14C-β, γ-propargyl alcohol and 14C-α-propargyl alcohol were synthesized from 14C-1, 2-acetylen and 14C-paraformaldehyde respectively, under the ordinary pressure. Some 14C, 3H-double labeled derivatives such as p-propargyloxybenzaldehydethiosemicarbazone, N- (p-propargyloxyphenyl) N'-allyl thiourea, γ-iodopropargyl-o-tolyl ether and 7-iodopropargyl-p-chlorophenylearbinol were synthesized from these alcohols.<BR>These are of use for demonstrating a relationship between a chemical structure of acetylenic compounds and it's pharmacological action or the site of bioactivity of acetylenic compounds in vivo.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 14 (6), 480-486, 1965

    Japan Radioisotope Association

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