Affinity for a Malignant Tumor and Organs of the Elements in Group IV of the Periodic Table

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  • 周期律第IV族元素のがんおよび臓器親和性

Abstract

In order to investigate the tumor affinity radioisotope, Tin (Sn-113), Germanium (Ge-68), Zirconium (Zr-95) and Hafnium (Hf-175+181) -the elements of group IV in the periodic table-were examined, using the rats which were subcutaneously trans-planted with Yoshida's sarcoma.<BR>Six preparations, 113Sn-dichloride, 113Sn-citrate, 95Zr-nitrate, 95Zr-oxalate, 15+181Hf-chloride and 68Ge-chloride were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each prepara-tion: 3 hours, 24 hours and 48 hours in all preparations but 68Ge-chloride, 1 hour, 3 hours and 24 hours in 68Ge-chloride. The radioactives of tumor, blood, muscle, liver, kidney and spleen were measured by a well-type scintillation counter, and retention values in every tissue including tumor were calculated (in per cent of administered dose per g-tissue weight) .<BR>113Sn had strong affinity for the malignant tumor, but it might have a disadvantage for the clinical application because retention value in the tumor was small and this element had very strog affinity for the bone and also considerably strong affinity for the inflammatory tissue. 113Sn accumulated in the bone was very slowly excreted, but it disappeared rapidly from the blood and soft tissues. 68Ge did not show any affinity for the malignant tumor, and disappeared very rapidly from the blood and soft tissue, and the majority of radioactivity was excreted in urine within first 3 hours. 175+181Hf and 95Zr did not have any affinity for the malignant tumor and disappeared slowly from the blood and soft tissue.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 22 (1), 7-11, 1973

    Japan Radioisotope Association

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