Studies on the Metabolism and Toxicity of Dinitrotoluenes

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  • MORI Masaaki
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • NARUSE Yoshifumi
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • KOZUKA Hiroshi
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

Bibliographic Information

Other Title
  • ジニトロトルエン類の代謝と毒性に関する研究
  • ジニトロトルエンルイ ノ タイシャ ト ドクセイ ニカンスルケンキュウ ラット
  • -On the Absorption and Excretion of Tritium-Iabelled 2, 4-Dinitrotoluene (<SUP>3</SUP>H-2, 4-DNT) in the Rat-
  • ―ラットにおける<SUP>3</SUP>H標識2, 4-ジニトロトルエン (<SUP>3</SUP>H-2, 4-DNT) の吸収および排泄について―

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Description

In order to investigate the detailed absorption and excretion of 2, 4-DNT in the rat, after the single oral administration of 3H-2, 4-DNT, the time-course of radioactivity level in blood, liver and digestive organ contents, and of biliary, faecal and urinary excretion were observed.<BR>Radioactivity level in blood reaches a peak at 6 hr after the administration and its halflife was about 22 hr. Maximum level of radioactivity in the liver was observed at 6 hr after the administration as well as in the blood. In contrast with the radioactivity levels in blood and liver, amount of radioactivity in small intestine content is markedly decreased for 6 hr after administration.<BR>In the biliary excretion, about 10 per cent of the radioactivity administered was excreted in bile within 24 hr. The excretion rate is rising steadily from 6 hr after administration and its peak time was 9-10 hr. In the faecal excretion, the most of the excretion radioactivity was concentrated on 6-9 hr faeces as reflected with the biliary excretion pattern. On the other hand, the most of the urinary excretion radioactivity was concentrated on 0-6 hr urine.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 27 (12), 715-719, 1978

    Japan Radioisotope Association

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