Affinity for a Malignant Tumor and Organs at the Elements in Group I of the Periodic Table

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  • ANDO Atsushi
    School of Paramedicine, School of Medicine, Kanazawa University
  • HISADA Kinichi
    Dept. of Nuclear Medicine, School of Medicine, Kanazawa University
  • ANDO Itsuko
    Dept. of Nuclear Medicine, School of Medicine, Kanazawa University

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Other Title
  • 周期律第I族元素のがんおよび臓器親和性
  • シュウキリツ ダイ 1ゾク ゲンソ ノ ガン オヨビ ゾウキ シンワセイ

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Abstract

In order to investigate the tumor affinity radioisotopes, 22Na, 42K, 86Rb, 134Cs, 64Cu, 110mAg and 198Au—the elements of group I in the periodic table—were examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma. Seven preparations, sodium chloride (22NaCl), potassium chloride (42KCl), rubidium chloride (86RbCl), cesium chloride (134CsCl), cupric chloride (64CuCl2), silver nitrate (110mAgNO3) and chloroauric acid (H198AuCl4) were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations but 64CuCl2, 24 hours in 64CuCl2. The radioactivities of the tumor, blood, muscle, liver, kidney and heart were measured by a well-type scintillation counter, and retention values (in every tissue including the tumor) were calculated in percent of administered dose per g-tissue weight.<BR>110mAgNO3 had considerably strong affinity for the malignant tumor. All preparations but 110mAgNO3 did not have any affinity for malignant tumor. The distribution of 42KCl in the rats very differed from that of 22NaCl, and was similar to the those of 86Rb and 134Cs. The distribution of 86RbCl in the rats was very similar to that of 134CsCl.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 25 (11), 699-705, 1976

    Japan Radioisotope Association

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